![]() Currently, multiple national laboratory monitoring recommendations exist 1, 2, 3, 4, 5. Routine laboratory monitoring is recommended for early identification of toxicity during treatment with conventional synthetic disease modifying antirheumatic drugs (csDMARDs). Our computational model predicts ALT elevations after the first follow-up test with good accuracy and can help in optimizing individual testing frequency. Respectively, at first follow-up, in addition to baseline ALT and psoriatic arthritis diagnosis, also ALT change from baseline was identified as an important predictor resulting in a test concordance index of 0.72. Among baseline variables, Lasso model with SIVS predicted subsequent ALT elevations of > 2 × ULN using higher ALT, csDMARD other than methotrexate or sulfasalazine and psoriatic arthritis diagnosis as important predictors, with a concordance index of 0.71 in the test cohort. Primary endpoint was reached in 82 patients (6.9%). Computational models for predicting incident ALT elevations were developed using Lasso Cox proportional hazards regression with stable iterative variable selection (SIVS) and were internally validated against a randomly selected test cohort (1/3 of the data) that was not used for training the models. Primary endpoint was alanine transaminase (ALT) elevation of more than twice the upper limit of normal (ULN) within 6 months after treatment initiation. For rheumatoid arthritis patients, diagnoses and csDMARD initiation/cessation dates were manually confirmed. Baseline and follow-up safety monitoring results were drawn from electronic health records. We identified inflammatory joint disease patients (N = 1196) initiating a csDMARD in Turku University Hospital 2013–2019. We aimed at developing a risk prediction model to individualize laboratory testing at csDMARD initiation. Once you take the time to learn how the program works, however, I think you'll find it to be an excellent little weapon to add to your Windows freeware arsenal.Frequent laboratory monitoring is recommended for early identification of toxicity when initiating conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). The amount of available settings are overwhelming, which is nice for the power user, but a bit intimidating to normal folks. The documentation is a bit outdated in parts (a few mentions of "New in v4"), yet comprehensive, and almost required to use Process Lasso effectively. You might not be able to delete it, but you can stop it from ever running! One very nice touch is the ability to automatically terminate any process. When spikes in processor or RAM use occur, Process Lasso highlights the events on the graph in green. All actions taken by the users or automatically by the ProBalance algorithm are recorded in a running list at the bottom of the screen. The main window of the interface includes a list of all PC processes, plus a processor use/responsiveness graph, and meters for CPU and RAM usage. (You also have the option to kill the engine when you quit the GUI.) You can use the GUI to configure your rules and settings and then close the interface to let the engine run in the background. Process Lasso exists as two basic applications - the core engine (ProcessGovernor.exe), which can be run all by itself and the graphical interface (ProcessLasso.exe), which allows users to configure Process Lasso, manage processes, and monitor activity. Everyone's computer is different, and to make the most of Process Lasso, I recommend (gasp!) reading the included documentation in order to avoid user-unfriendly messages like "If you don't know what this message means, STOP NOW." In some ways, Process Lasso is great for newbies - install it, run it, forget about it, and Process Lasso will moderate the process activity on your computer in order to maintain optimal performance (based on the default configuration settings that make up Process Lasso's ProBalance algorithm). ![]() The interface is outdated and not beginner friendly, but Process Lasso offers very useful features in a powerful little package. It lets users set default priorities and CPU affinities for specific processes, establish rules for how processes behave, and also create alerts and automatic events for when processes misbehave or use too much memory. Well, Process Lasso is like the peanut butter for Process Explorer's chocolate. At, we've long recommended the excellent Mark Russinovich-created and Microsoft-supplied Process Explorer freeware, which provides scads of info on all of your Windows PC processes and options for managing them.
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![]() Normally, we are using 64-bit and we need DaRT 64-bit, but for 32-bit version of Windows, you will need DaRT 32 bit. You also have to consider about the architecture of Windows. For example, DaRT 10 is for Windows 10 and Windows 11. However, you have to make sure you are using the right version of DaRT for the Windows. This tool would make you productive and helps you to identify and fix problem quicker. You could interact with menu and perform actions to repair your device. You will have to boot with DaRT and you will be presented with a menu with a nice GUI of troubleshooting tools. Instead of inserting Windows installation media, you may insert a DaRT and start troubleshooting. Let say, you are facing issue when Windows failed to boot, and you have to physically present and troubleshoot it. I always advise IT Professional to create a DaRT and have them in a USB and it will come handy one day. There you have set of valuable tools including something called DaRT. However, in case you are IT administrator for a large company, and you are Software Assurance customers, you do have access to set of tools known as Microsoft Desktop Optimization Pack (MDOP). However, there are cases where system failed to boot or start and then we need to perform other tasks and when everything failed, then we have to reinstall or repair the Windows. Whenever we are able to boot into the Windows, then it is good to go and we are able to perform steps to fix the system. In other cases, we are using third-party tools or system imaging to save the system. In the past we used to carry Windows installation media on a DVD or we are carrying it inside a USB and attempt to repair a system and if that failed, then reinstall Windows. In case you are in charge of administrating Windows devices, you will need a tool to help you to recover the system faster. However, there are cases where we have to be physically present in front of the device to repair the system. Sometimes, we might be able to solve the problem remotely and back everything to its right place. This is common to fail system failure in IT environment, no matter what platform or technology we are using, you will face problem of system failure and errors. These two teams met earlier this month with Vancouver winning handily, but the Titans are coming off that stunning loss to the Valiant. ![]() Lane "Surefour" Roberts has had a down year, but he remains the team's spiritual leader and has helped rally the one-two duo of Jun Woo "Void" Kang and Gui-un "Decay" Jang, while Jonas "Shaz" Suovaara's Zenyatta keeps the machine oiled up and running. But they're still fourth in the overall league standings and have their own roster of heavy hitters. The other Los Angeles team, the Los Angeles Gladiators, hasn't had their best Stage of the season so far. Led by league leader in Eliminations MinSoo "SeoMinSoon" Seo, the Titans are clearly going to look to crush whoever's next in line. That clearly isn't going to stand if you're Vancouver. Wait, what the heck happened last week? Wasn't there a time at the start of the season when the Los Angeles Valiant looked hapless and left in the dust by the rest of the field? Yeah, that Los Angeles Valiant sent the Vancouver Titans crashing to their first defeat of the regular season. San Francisco Shock - 1:45PM PT (Disney XD) Los Angeles Valiant - 5:30PM PT (Disney XD) Photo credits: Robert Paul for Blizzard Entertainment Stage 3, Week 4 schedule Overall Standings after Stage 3, Week 3 (Win-Loss, Map Differential) Stage 3 Standings (Win-Loss, Map Differential) ![]() Let's take a look at the Stage 3 and overall standings heading into Stage 3, Week 4. With the Overwatch League back and fully underway, Shacknews is here to help fans, be they old, new, or curious, keep up with the state of the league for the rest of the season. And as the Overwatch meta continues to evolve, so too do the teams looking to claim the league's second championship. The Overwatch League's sophomore season continues! Season 2 is well underway and all of last year's teams are back, along with a handful of new expansion teams. ![]() ![]() Inspect the cables for any cracks, corrosion, or other obvious signs of wear that may impact their performance. Check and clean the battery terminals and connectors to rid them of any corrosion buildup. If your battery is holding adequate charge, the cables or connectors may be faulty. If the voltmeter reads below 12 volts, your battery most likely is the problem and may need to be jumped or replaced. Use a voltmeter to check the condition of your battery. If the engine cranks slowly or doesn't crank at all, it's possible your battery may be dead or low. If the engine won't crank but other lights and gauges work correctly, check that the gear shift is in neutral. Most outboards will not crank if the boat is in gear. If your boat has a battery switch, ensure that it's switched to the on position and try again. If everything else is dead too, check the outboard's main fuse. If the engine doesn't crank at all, turn the key to the on position and check to see if other lights and gauges operate correctly. With any luck and with the help of these common outboard starting fixes, you'll be able to identify and fix the issue in no time and save the day (as well as some money). You're finally set to take off and go to crank the motor only to find that the boat won't start. Along with a few choice words, your first reaction will probably be something along the lines of "oh great, I wonder how much this is going to cost me".ĭon't fret just yet! As with any modern motor, there are simple steps to follow to identify the source of the problem and begin troubleshooting the issue. We've all been there - your boat is in the water and packed with guests and gear. ![]() Ad creativity: With google trends data we can outscore our competitor’s ad campaign and social media content by creating Creative ads & posts related to thos e trending topics.Reliance Retail opened its second Trends concept store at Ambience Mall in Gurugram, Haryana.Finding trending topics writing based on those trending topics can help us drive traffic to our website. Content marketing & SEO: We can use Google Trends to know what people in the market your focus is searching for.We can also use Google Trends to find unrelated trending terms you need to set as negative keywords so that trending search doesn’t affect your costs much. Paid search: The Data from google trends can be used for PPC campaigns to help with cost planning and also inventory stocking.Below are some of the major uses of google trends in Online Marketing & SEO: We can use the data found in Google Trends for several different SEO & Online marketing purposes. Why Google Trend is vital for SEO and Online marketing? This option is very useful for marketers to choose keywords. We also have an option to compare between two search times based on the location, time frame, category or industry, and much more. Google Trends also shows us similar search terms & how search interest based on sub-regions We can change the location, time frame, category or industry, and type of searches such as web, news, shopping, or YouTube for more exact data. We can also enter a search term into the search box to see how search volume has varied for that particular term over time and in different locations. You can dig into a topic for further information. We can explore Google Trends from the top down by visiting the tool and seeing what searches are currently trending. Web Search: This option helps you to select whether you want to view the chart for web searches or combinations of universal searches such as Google News, Google Images, or video search with YouTube or Google Shopping. ![]() Categories: Especially for ambiguous words or differing user intentions you can display the result relevant to you here.Time period: You can choose the time period that is whether you want the hourly, weekly or monthly data from 2004 to present”.Region: You can choose whether you want to view based on location – the “worldwide” chart or individual countries.The other values in the chart show the relativistic demand corresponded to the demand peak. The highest value is 100 this means the highest search interest. Here the search volume is given in approx values. In this, Google offers the chance to find the search interest for an entered keyword, both historically back to 2004 as well as the minute-by-minute progress over the past hour. In Google Trends, the “Explore” function is the most exciting for content marketing and Search Engine Optimization. ![]() The most popular search queries in the world are documented in real-time and have been able to register the highest growth of search queries at the moment and are usually supported by entities such as a person, city, or event. What does Google Trends offer?Ĭurrent trends & topics are shown on the homepage of Google Trends. Google Trends gives data related to keywords which Includes search Volume Index and Demographics information about searching users. This is really helpful for related keyword research and also to discover certain event-triggered spikes in keyword search volume. Google Trends is a search trend feature that shows the interest of Google users for certain search terms which is relative to the website’s total search volume in a given period. We’ve got a range of different styles – including kitchen clocks and kids’ clocks.īrowse our range of wall clocks and shop our full collection of home accessories online and in-stores today. Wall ClocksĪdd a sense of timelessness to your home with B&M’s range of wall clocks. ![]() These products work for most iPhones and Android phones and are great if you like to charge your phone at night. One of many items available from our Alarm Clocks. ![]() Luckily, at B&M, you’ll find a great range of alarm clocks that also work as wireless phone chargers. Shop Digital Desktop Clock,electronic Digital Alarm Clocks For Bedroom Home,with Time/calendar/temperatu. The Clock app also makes it easy to quickly check times around the world and brings set alarms, timers, and reminders on your PC. Digital Desktop Clock (Black) with LED Electronic Display Having Alarm, Calendar, Month, Date, time, and Temperature Functions- Available at Office, Home and. Build healthy digital habits and get more done with Focus Sessions. Whilst most people have moved on to using their mobiles as their alarm clocks, sometimes you just can’t beat a good old alarm clock – especially for those all-important events that you have to be up early for. The Clock app is your hub for time management and focus on Windows. Pen Pencil Holder Digital LCD Desk Alarm Clock Pen Holder Calendar /Timer Temperature Desktop Clock - Buy Digital Clock Pen Holder at best price of Rs. You’ll find all that and more! Alarm Clocks It is a world clock app that can also serve as a time zone. World Clock - Time Zones is a free productivity program for PC developed by Time and Date AS. Digital Wall Clock with Remote Control,11.5' LED Desktop Alarm Clock for Office Home Living Room,with Calendar, Temperature,for Impaired Vision People, Age Seniors. ![]() It syncs with Google Calendar, iCloud Calendar, Facebook and. The options of the clock gadget allow you to enable the second hand or to change the. Whether you’re teaching your little one how to tell the time, want a trusty clock for the kitchen, or are looking for an alarm clock that also functions as a wireless charger for your mobile, look no further than B&M. World clock and time zone conversion app for PC. LED Alarm Clock Digital Desktop Clock Voice Control Wooden Temperature Wireless Charger for Phone(6.7 x 3.1 x 2.8inch-Wood Color). The poster board-sized device hangs on your wall and displays the goings-on either in day-to-day mode or full monthly calendar style. Here you can add a gadget to your desktop by double-clicking on it. It allows them to choose from many of styles and it adds extra functionality like creating alarms.It’s never been a better time to invest in a clock for your home, and at B&M we’ve got a great range of kids' clocks, mantel clocks, alarm clocks and more. Users who like to customize look of their desktop will love ClocX. Advanced users can even create their own styles or edit any of current styles just using a graphic editor and Notepad. ![]() No adware, spyware or toolbars are included.ĬlocX allows users to customize its look completely by selecting one of many styles and various options. This 64-bit version is made for running on 64-bit operating systems Windows XP/Vista/7/8 圆4.ĬlocX supports many features like anti-aliasing, transparency and mouse-over transparency, over 400 included customizable skins, interface in 34 languages, click through, customizable priority, auto-load, alarms, calendar and many more.ĬlocX is completely free and clean software. Configurable level of transparency will make ClocX looking cool and matching your favorite Windows theme. Flip clock with 12 or 24 hour time format. ClocX can be configured to stay on top of other apps or be pinned to desktop, providing you with a nicer and more comfortable way to check time. Customizable Widgets For Notion Pages - Weather, Clocks, Calendar, Progress Bar, Buttons. It features extra functionality such as an alarm system and can be customized with literally hundreds of different beautiful skins. flexible multifunctional digital stopwatch / countdown timer / clock software for PC. ClocX is much more than just a simple replacement for the Windows standard clock. Stopwatch Online Clock Timer Online Countdown Timer Calendar. , Acronis True Image WD Edition Free download with link. By choosing this option, after the first successful backup, your backup and replication will be done simultaneously. This program can clone drives and back up the operating system, applications, settings, an. With Acronis Cyber Protect Home Office, you also have the ability to automatically replicate local backups in the Acronis Cloud, so you always have an off-site copy of your data available without having to manage a separate backup plan. Download Software, Firmware and Drivers for WD Products. Subscriptions to the Advanced and Premium editions of Acronis Cyber Protect Home Office (formerly Acronis True Image) include cloud storage, as well as cloud-based features and "anywhere access" to your data. The cloud is a convenient way to store your files off-site, where they are safe from local damage. ![]() "The cloud" is a term that describes a remote network of computers and servers that you access via the internet. That way, if a fire or flood damages both your original files and the local backup, the off-site copy is available to use for recovery. Acronis recommends the 3-2-1 backup rule, which includes storing three copies of your data on at least two different types of media (such as external hard drives, network drives, and NAS devices) and keeping one copy off-site. ![]() ![]() Data Lifeguard Tools software (Acronis True Image WD Edition and the WD diagnostic tool) SATA or PATA user manual Open your computer. Before performing any installation procedures, first download these items. Computer backups need to be stored someplace safe. Installing a WD hard drive takes just a few simple steps. ![]() ![]() Most Awarded Carolina Reaper Hot Sauce on the market - 15 Industry Awards XTREME REGRET Is an intense SUPER HOT - hot sauce made with the top 2 worlds hottest peppers - Carolina Reaper. This is an extremely spicy sauce with a killer flavor. That top end is just as hot as or hotter than standard pepper spray. REAPER SAUCE Has a savory sweet smooth heat from black cherries, cranberries, Kentucky Bourbon and the hottest pepper in the world - Carolina Reaper Pepper. Daves Gourmet Carolina Reaper Hot Sauce is made with the chile that is widely known as one of the hottest. ![]() Advent calendars can take a variety of forms, styles and budgets, from calendars designed for wine lovers to fun ones that would make great gifts for kids - and of course, the classic chocolate option.įrom intricate beauty Advent calendars to options filled with crafts, toys, mini jams and more, shop the best Advent calendars of 2023 below. Carolina Reaper’s range from 1,400,000 Scoville heat units to a blistering 2,200,000. You can check your local availability of the new Cheetos variety from the Walmart website (they dont seem to be available at all here in the Los Angeles area). Recently, though, one of the most popular ways to escalate the excitement as Santa heads near is the beloved Advent calendar. Flamin Hot Sweet Carolina Reaper Cheetos currently garner an average rating of 3.8 out of 5 (with 13 reviews in total). FYI: We're officially 15 weeks away from Christmas! Those eager to spread cheer and joy ahead of the holiday season are stocking up on matching family pajamas and daydreaming about hunkering down with puzzles, board games and piping mugs of hot cocoa and mulled wine. Pepper Joes Blueberry Reaper Hot Sauce - Premium All-Natural Carolina Reaper Sauce - Made with Worlds Hottest Chili Pepper and Ripe Blueberries - 5 Ounces USD 22.81 You save 0. ![]() We are not a satellite office hub doing business from another state like our competitors. See our Home Page for more details of why we’re different. Your 1st Choice for Original Log Cabin Homes and Cypress Log Cabins. Not with Log Home Guys, right the first time without the hidden cost. Now the log home company needs more or different materials which cost you more and delays your project. The worst part is after the changes have been made by the engineer of record you realize that the base drawing have changed which now have to go back to log home company. Then just to find out from the building department that you need to go hire a local engineer who will redraw and stamp costing you thousands. Most companies will give you a drawing leading you to believe it’s all you need. Ready for permitting to begin the building process. With Log Home Guys you can be rest assured that our plans will be engineered right the first time. Islamorada is billed as the Sports Fishing Capital of the World.įort Jefferson, a massive but unfinished coastal fortress in the Florida Keys, is composed of over 16 million bricks and is the largest masonry structure in the Americas. The first graded road built in Florida was Old Kings Road in 1763. Two million pounds of shrimp are delivered to Fernandina docks annually. Nearly 80 percent of the state’s intake of sweet Atlantic white shrimp is harvested in Amelia Island waters. Long an unofficial symbol of the state, the alligator originally symbolized Florida’s extensive untamed wilderness and swamps. ![]() In 1987 the Florida legislature designated the American alligator (Alligator mississippiensis) the official state reptile. ![]() The Saint John’s River is one of the few rivers that flows north instead of south. The DeSoto encampment site located east of the Florida State Capitol based on archaeological excavations is believed to be the first place Christmas was celebrated in the continental United States. He discovered the state and named it for all of the flowers he saw blooming everywhere he went. One of the first Florida facts is that “La Florida” was named by Ponce de Leon in 1513. Balanced in Old Time Tradition using hand tools and methods handed down from the pioneer’s than built this great country.īelow is an old photo showing the different styles of the Adze used in the building of the Original Log Cabin Homes. Log Home Guys being proud producer of Florida Log Homes is also happy to produce old time authentic style Appalachian Cracker true hand hewn-logs, post, fireplace mantels, beams and more in Heart-Cut Cypress, Pine, and Western Red Cedar. ![]() Give us a chance and find out why Log Home Guys is different. I’m sure your asking why would we support our competitors? Because we know we can’t sell every customer and we know it’s the best thing for the customer to purchase Cypress, the best wood in the log home market today. We support BK Cypress Log Homes and Cracker Style Log Homes. With today’s new age Florida Log Homes verses the old cracker style log homes and original log cabin homes, we are building strong, energy efficient smart homes that will last the family for many generations. This allows the interior log wall finish to stay clean and bright. In today’s Log Home, most customers use a clear coat water based sealer with UV stabilizers and Low E windows and doors. In the Log Homes of the past, the log walls on the interior of the home was finished with Tung Oils which darkened over time dropping light levels. Log Homeowners today are incorporating lot’s of great lighting which is needed due to wood doesn’t reflect light as well as drywall. Several things have changed over the years one is the lighting. Log homes today are able to be heated and cooled with smaller units adding to longterm savings due to their overall efficiency. Log Home customers today use state of the art spray insulation and high-efficiency windows and doors, this with a combination of full logs drops their electric utility bills to a fraction of a typical home. Log Homes can actually take more stress loads in a Hurricane than a traditional CBS block home. Today’s log homes average a whopping 30 to 45% more energy efficient than a typical standard conventional spec home.Ĭustomers that build log homes today are focusing on lowering their electrical footprint and designing some of the strongest homes on the market today. Although Florida Log Homes of the past have their own pristine, New Florida cypress log homes have many new benefits. Noting differences in the feeding habits of the finches, Darwin wrote that cactus finches “may often be seen climbing about the flowers of the great cactus trees.” Seeing the diversity of beaks and other structures in the closely related finches, he wrote in his notebook, “one might really fancy that one species had been taken and modified for different ends.”ĭarwin elaborated on this idea when he published his intellectual bombshell, the “Origin of Species,” some 25 years later in 1859. “Some of the craters, surmounting the larger islands, are of immense size, and they rise to a height of between three and four thousand feet.” When Charles Darwin first saw the Galapagos Islands he described them as 10 islands “situated under the equator.” He noted that they originated as volcanoes and were pockmarked with craters. “This higher level is both biologically relevant and functionally important for shaping of elongated beaks, which are used in a specialized manner to probe cactus flowers and fruit for pollen, nectar, and seeds.” The same surge of calmodulin was not found in more blunt-beaked ground finches. “We found that calmodulin was indeed expressed at detectably higher levels in cactus finches compared to ground finches, and thus associated with their longer beaks,” says Clifford Tabin, professor of genetics. This protein had never before been implicated in the development of the skulls and faces of any birds. The investigation soon focused on calmodulin as the switch that can turn on genes involved in increasing beak length. This activity was then matched with the size and shapes of adult beaks. In the Department of Genetics at Harvard Medical School, 26 bird embryos were examined, using gene chips that reveal which genes are most active in the heads of the developing finches. To avoid disruption and abandonment of the nests, the researchers took only the third eggs laid. Female finches lay clutches of four to five eggs, one per day. ![]() Members of the research team received permission to collect finch eggs from the Galapagos National Park, a group of rocky islands in the Pacific Ocean, about 600 miles west of Ecuador. These signals alter the behavior of cells responsible for beak sculpturing. “Calmodulin is a protein that binds and activates certain enzymes, which triggers a signal that eventually turns specific genes on or off,” explains Arkhat Abzhanov, an evolutionary biologist at Harvard. Using modern genetic analyses, they found a molecule that regulates genes involved in shaping the beaks of Darwin finches. Researchers at Harvard Medical School have taken the story one step further. These adaptations make them more fit to survive on available food. Beaks of warbler finches are thinner and more pointed than both. So-called cactus finches boast longer, more pointed beaks than their relatives the ground finches. The birds he saw on the Galapagos Islands during his famous voyage around the world in 1831-1836 changed his thinking about the origin of new species and, eventually, that of the world’s biologists.ĭarwin wondered about the changes in shape of bird beaks from island to island. (Staff photo Kris Snibbe/Harvard News Office)ĭarwin’s finches are the emblems of evolution. He and his colleagues discovered a molecule that controls the length of the birds’ beaks, which enhance their ability to survive on available seeds and insects. Arkhat Abzhanov checks out a selection of Darwin’s finches preserved in the Harvard Museum of Natural History. |
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