Currently, multiple national laboratory monitoring recommendations exist 1, 2, 3, 4, 5. Routine laboratory monitoring is recommended for early identification of toxicity during treatment with conventional synthetic disease modifying antirheumatic drugs (csDMARDs). Our computational model predicts ALT elevations after the first follow-up test with good accuracy and can help in optimizing individual testing frequency. Respectively, at first follow-up, in addition to baseline ALT and psoriatic arthritis diagnosis, also ALT change from baseline was identified as an important predictor resulting in a test concordance index of 0.72. Among baseline variables, Lasso model with SIVS predicted subsequent ALT elevations of > 2 × ULN using higher ALT, csDMARD other than methotrexate or sulfasalazine and psoriatic arthritis diagnosis as important predictors, with a concordance index of 0.71 in the test cohort. Primary endpoint was reached in 82 patients (6.9%). Computational models for predicting incident ALT elevations were developed using Lasso Cox proportional hazards regression with stable iterative variable selection (SIVS) and were internally validated against a randomly selected test cohort (1/3 of the data) that was not used for training the models. Primary endpoint was alanine transaminase (ALT) elevation of more than twice the upper limit of normal (ULN) within 6 months after treatment initiation. For rheumatoid arthritis patients, diagnoses and csDMARD initiation/cessation dates were manually confirmed. Baseline and follow-up safety monitoring results were drawn from electronic health records. We identified inflammatory joint disease patients (N = 1196) initiating a csDMARD in Turku University Hospital 2013–2019. We aimed at developing a risk prediction model to individualize laboratory testing at csDMARD initiation. Once you take the time to learn how the program works, however, I think you'll find it to be an excellent little weapon to add to your Windows freeware arsenal.Frequent laboratory monitoring is recommended for early identification of toxicity when initiating conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). The amount of available settings are overwhelming, which is nice for the power user, but a bit intimidating to normal folks. The documentation is a bit outdated in parts (a few mentions of "New in v4"), yet comprehensive, and almost required to use Process Lasso effectively. You might not be able to delete it, but you can stop it from ever running! One very nice touch is the ability to automatically terminate any process. When spikes in processor or RAM use occur, Process Lasso highlights the events on the graph in green. All actions taken by the users or automatically by the ProBalance algorithm are recorded in a running list at the bottom of the screen. The main window of the interface includes a list of all PC processes, plus a processor use/responsiveness graph, and meters for CPU and RAM usage. (You also have the option to kill the engine when you quit the GUI.) You can use the GUI to configure your rules and settings and then close the interface to let the engine run in the background. Process Lasso exists as two basic applications - the core engine (ProcessGovernor.exe), which can be run all by itself and the graphical interface (ProcessLasso.exe), which allows users to configure Process Lasso, manage processes, and monitor activity. Everyone's computer is different, and to make the most of Process Lasso, I recommend (gasp!) reading the included documentation in order to avoid user-unfriendly messages like "If you don't know what this message means, STOP NOW." In some ways, Process Lasso is great for newbies - install it, run it, forget about it, and Process Lasso will moderate the process activity on your computer in order to maintain optimal performance (based on the default configuration settings that make up Process Lasso's ProBalance algorithm). The interface is outdated and not beginner friendly, but Process Lasso offers very useful features in a powerful little package. It lets users set default priorities and CPU affinities for specific processes, establish rules for how processes behave, and also create alerts and automatic events for when processes misbehave or use too much memory. Well, Process Lasso is like the peanut butter for Process Explorer's chocolate. At, we've long recommended the excellent Mark Russinovich-created and Microsoft-supplied Process Explorer freeware, which provides scads of info on all of your Windows PC processes and options for managing them.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |